To find out if the presence of proline was a cause or a consequence of depressive mood, participants’ microbiota was transplanted into mice. Mayneris-Perxachs, a Miguel Servet researcher at the IDIBGI. “The microbiota of patients with high proline consumption but low plasma levels of proline was similar to the microbiota associated with low levels of depression and was enriched in bacterial genes involved in the transport and metabolism of proline”, states Dr. Thus, it was observed that circulating proline levels depended on the microbiota. When studying these people’s intestinal microbiota, a relationship was also observed between depression and bacteria, as well as between depression and bacterial genes associated with proline metabolism. Proline levels, depending on the microbiotaīut not everyone who had a high intake of proline was more depressed. Confirming this, when plasma metabolomics was evaluated, the concentration of proline emerged as one of the metabolites most associated with indicators of depression. Josep Trueta in Girona and director of the Department of Medical Sciences at the University of Girona. Fernández-Real, of the IDIBGI, and also head of the Endocrinology Section at Hospital Dr. “We were surprised that what was most associated with depression, evaluated through this questionnaire, was the consumption of proline,” says Dr. Participants also completed a questionnaire to measure their depressive mood. To reach these conclusions, on the one hand, the type and amount of amino acids in the diet of the participants were analyzed. Rafael Maldonado, Neuropharmacology-Neurophar research group Credit: UPF According to the study, a diet rich in proline is linked to an increased risk of depression.ĭr. Proline is a nonessential amino acid and is found in grass-fed beef, pasture-raised chicken, gelatin, bone broth, organ meats like liver, and cage-free egg yolks. Newly released research confirms the link between a certain amino acid called proline and depression. There are 20 different amino acids, of which 9 are considered essential amino acids because they cannot be made by the body and must come from food. To carry out bodily functions, the body then combines the amino acids in different ways. When a person consumes food containing protein, the protein is broken down into amino acids by the digestive system. A new study confirms the link between an amino acid present in diet and depression.Ī new study shows, in humans, mice, and flies, that elevated plasma levels and a diet rich in the amino acid proline cause a more severe state of depression.Īmino acids are monomers that are the building blocks of protein.
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